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An Open-Label, Multiple-Ascending Dose Study to Assess the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Different Dose Levels of Povetacicept in Subjects With Autoantibody-Associated Glomerular Diseases (RUBY-3)

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Trial Profile

An Open-Label, Multiple-Ascending Dose Study to Assess the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Different Dose Levels of Povetacicept in Subjects With Autoantibody-Associated Glomerular Diseases (RUBY-3)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 24 Nov 2025

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At a glance

  • Drugs Povetacicept (Primary)
  • Indications IgA nephropathy; Lupus nephritis; Membranous glomerulonephritis
  • Focus Adverse reactions
  • Acronyms RUBY-3
  • Sponsors Alpine Immune Sciences

Most Recent Events

  • 17 Nov 2025 According to a Vertex pharma media release, data from this trial will be presented at American Society of Nephrology Kidney Week
  • 08 Nov 2025 Results presented in a Vertex pharma media release.
  • 08 Nov 2025 According to a Vertex pharma media release, company announced updated data for povetacicept (pove) in IgA nephropathy (IgAN) and primary membranous nephropathy (pMN) from the ongoing RUBY-3 trial at the American Society of Nephrology (ASN) Kidney Week 2025 in Houston, Texas. Results were presented today as a late-breaking oral presentation (SA-OR091) and included interim data from the open-label Phase 1/2 RUBY-3 trial, where adults with IgAN and pMN received pove subcutaneously every 4 weeks.

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