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A Phase 2 Randomized, Open-label Study to Evaluate the Safety and Efficacy of Broadly Neutralizing Antibodies (bNAbs) GS-5423 and GS-2872 in Combination With the Capsid Inhibitor Lenacapavir as Long-Acting Treatment Dosed Every 6 Months in Virologically Suppressed Adults With HIV-1 Infection

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Trial Profile

A Phase 2 Randomized, Open-label Study to Evaluate the Safety and Efficacy of Broadly Neutralizing Antibodies (bNAbs) GS-5423 and GS-2872 in Combination With the Capsid Inhibitor Lenacapavir as Long-Acting Treatment Dosed Every 6 Months in Virologically Suppressed Adults With HIV-1 Infection

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 27 Apr 2025

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At a glance

  • Drugs Lenacapavir (Primary) ; Lenacapavir (Primary) ; Teropavimab (Primary) ; Zinlirvimab (Primary) ; Abacavir/dolutegravir/lamivudine; Bictegravir/emtricitabine/tenofovir alafenamide; Cobicistat/darunavir/emtricitabine/tenofovir alafenamide; Emtricitabine/rilpivirine/tenofovir alafenamide
  • Indications HIV-1 infections
  • Focus Therapeutic Use
  • Sponsors Gilead Sciences

Most Recent Events

  • 12 Mar 2025 According to a Gilead Sciences media release, the company presented data at the Conference on Retroviruses and Opportunistic Infections (CROI 2025).
  • 12 Mar 2025 Results presented in the Gilead Sciences Media Release.
  • 07 Nov 2024 According to a Gilead Sciences media release, data from this study will be presented at the International Congress on Drug Therapy in HIV Infection (HIV Glasgow 2024), taking place from November 10-13.

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