Trial Profile

First-in-human Dose Escalation and Expansion Study With the SIRPα-directed Monoclonal Antibody BYON4228 Alone and in Combination With Rituximab to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy in Patients With Relapsed/Refractory CD20 Positive B-cell Non-Hodgkin's Lymphoma (NHL)

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 25 Jan 2026

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At a glance

Drugs BYON 4228 (Primary) ; Rituximab (Primary)
Indications Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
Focus Adverse reactions; First in man
Acronyms BYON4228.001
Sponsors Byondis

16 Jan 2026 Planned End Date changed from 1 Dec 2025 to 1 May 2026.
16 Jan 2026 Planned primary completion date changed from 1 Oct 2025 to 1 Feb 2026.
16 Jan 2026 Status changed from recruiting to active, no longer recruiting.

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