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First-in-human Dose Escalation and Expansion Study With the SIRPα-directed Monoclonal Antibody BYON4228 Alone and in Combination With Rituximab to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy in Patients With Relapsed/Refractory CD20 Positive B-cell Non-Hodgkin's Lymphoma (NHL)

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First-in-human Dose Escalation and Expansion Study With the SIRPα-directed Monoclonal Antibody BYON4228 Alone and in Combination With Rituximab to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy in Patients With Relapsed/Refractory CD20 Positive B-cell Non-Hodgkin's Lymphoma (NHL)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 13 Mar 2025

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At a glance

  • Drugs BYON 4228 (Primary) ; Rituximab (Primary)
  • Indications Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; First in man
  • Acronyms BYON4228.001
  • Sponsors Byondis

    • Most Recent Events

    • 26 Nov 2024 Planned primary completion date changed from 1 Oct 2024 to 1 Oct 2025.
    • 12 Dec 2023 Trial design presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 23 Nov 2023 Mantle-cell-lymphoma is added to indications.

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