Trial Profile

A Phase 2, Open-label, Multicenter Study Investigating Oncolytic Immunotherapy in Combination With Other Therapy in Patients With Locoregionally Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 13 Mar 2025

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At a glance

Drugs Nivolumab (Primary) ; RP 3 (Primary) ; Carboplatin; Paclitaxel
Indications Carcinoma; Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Mouth neoplasm; Oropharyngeal cancer; Squamous cell cancer
Focus Therapeutic Use
Sponsors Replimune

21 Dec 2023 Status changed from not yet recruiting to discontinued.
25 Oct 2023 Planned initiation date changed from 30 Sep 2023 to 30 Jan 2024.
03 Aug 2023 According to a Replimune media release, due to the global shortage of cisplatin and carboplatin, initiation of this study is currently on hold until sufficient supplies of these agents are available.

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