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A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efgartigimod PH20 SC Administered by Prefilled Syringe in Adult Participants With Thyroid Eye Disease

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Trial Profile

A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efgartigimod PH20 SC Administered by Prefilled Syringe in Adult Participants With Thyroid Eye Disease

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 05 Jun 2026

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At a glance

  • Drugs Efgartigimod alfa (Primary)
  • Indications Graves ophthalmopathy
  • Focus Registrational; Therapeutic Use
  • Acronyms UplighTED
  • Sponsors argenx

Most Recent Events

  • 05 Jun 2026 Planned End Date changed from 1 Sep 2027 to 31 Mar 2026.
  • 15 Dec 2025 According to an argenx media release, Data from the studies will be shared at a future medical meeting.
  • 15 Dec 2025 According to an argenx media release, company announced that the Phase 3 UplighTED studies evaluating efgartigimod subcutaneous (SC) (efgartigimod alfa and hyaluronidase-qvfc) in adults with moderate to severe thyroid eye disease (TED) will be discontinued. decision is based on the recommendation from an Independent Data Monitoring Committee (IDMC) to stop the trials for futility following its review of data from a pre-specified interim analysis.

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