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First-in-Human Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of the BTK Degrader, ABBV-101, in Participants With B-cell Malignancies

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Trial Profile

First-in-Human Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of the BTK Degrader, ABBV-101, in Participants With B-cell Malignancies

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 02 Jul 2025

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At a glance

  • Drugs ABBV-101 (Primary)
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man
  • Sponsors AbbVie

Most Recent Events

  • 31 Jan 2025 Planned number of patients changed from 128 to 244.
  • 31 Jan 2025 Planned End Date changed from 1 Apr 2029 to 1 Mar 2031.
  • 31 Jan 2025 Planned primary completion date changed from 1 Jun 2027 to 1 Mar 2031.

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