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A Randomized, Crossover, Double Blind, Placebo Controlled, Phase 2 Study to Evaluate the Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors, in Adults with Hypertension and Chronic Kidney Disease with Albuminuria

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Trial Profile

A Randomized, Crossover, Double Blind, Placebo Controlled, Phase 2 Study to Evaluate the Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors, in Adults with Hypertension and Chronic Kidney Disease with Albuminuria

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 16 Dec 2025

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At a glance

  • Drugs Lorundrostat (Primary) ; Dapagliflozin
  • Indications Hypertension; Resistant hypertension
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Acronyms Explore-CKD
  • Sponsors Mineralys Therapeutics

Most Recent Events

  • 08 Nov 2025 According to Mineralys Therapeutics, media release, data from this trial published in a late-breaking clinical trials session at American Society of Nephrology (ASN) Kidney Week 2025
  • 08 Nov 2025 Results published in the Media Release
  • 21 Oct 2025 According to Mineralys Therapeutics, media release, data from this trial will be presented in a late-breaking clinical trials session at American Society of Nephrology (ASN) Kidney Week 2025

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