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A Phase 1/2 Open-label Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

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Trial Profile

A Phase 1/2 Open-label Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 11 Aug 2026

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At a glance

  • Drugs Temozolomide (Primary) ; Zedoresertib Debiopharm (Primary)
  • Indications Astrocytoma; Glioblastoma
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Debiopharm

Most Recent Events

  • 10 Feb 2025 Planned number of patients changed from 132 to 116.
  • 18 Jul 2024 Planned number of patients changed from 120 to 132.
  • 29 Jan 2024 Planned number of patients changed from 89 to 120.

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