Trial Profile

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

Status: Recruiting

Phase of Trial: Phase II/III

Latest Information Update: 28 May 2025

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At a glance

Drugs Cobimetinib (Primary) ; Vemurafenib (Primary)
Indications Cancer; Carcinoma; Colorectal cancer; Erdheim-Chester disease; Glioma; Laryngeal cancer; Leukaemia; Malignant melanoma; Multiple myeloma; Non-small cell lung cancer; Ovarian cancer; Thyroid cancer
Focus Therapeutic Use
Acronyms DETERMINE

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