Trial Profile

A Phase I, Fixed-sequence, Open-label Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Substrates of Human Transporters Digoxin (P-gp), Rosuvastatin (OATP1B1/3), Metformin (OCT2, MATE1/2K), and Furosemide (OAT1/3) in Healthy Male Subjects

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 21 Jan 2025

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At a glance

Drugs Digoxin (Primary) ; Furosemide (Primary) ; Metformin (Primary) ; Rosuvastatin (Primary) ; Savolitinib (Primary)
Indications Colorectal cancer; Gastric cancer; Non-small cell lung cancer; Oesophageal cancer; Prostate cancer; Renal cell carcinoma
Focus Pharmacokinetics
Sponsors AstraZeneca

12 Jul 2023 Status changed from active, no longer recruiting to completed.
22 Jun 2023 Planned End Date changed from 18 Jul 2023 to 26 Jun 2023.
22 Jun 2023 Planned primary completion date changed from 18 Jul 2023 to 26 Jun 2023.

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