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DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations. Treatment Arm 02: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High TMB or MSI-high or Proven CMMRD Disposition.

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Trial Profile

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations. Treatment Arm 02: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High TMB or MSI-high or Proven CMMRD Disposition.

Status: Recruiting
Phase of Trial: Phase II/III

Latest Information Update: 30 May 2025

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At a glance

  • Drugs Atezolizumab (Primary)
  • Indications Haematological malignancies; Solid tumours
  • Focus Therapeutic Use
  • Acronyms DETERMINE

Most Recent Events

  • 24 Oct 2023 Status changed from not yet recruiting to recruiting.
  • 26 Jun 2023 Planned initiation date changed from 1 Apr 2023 to 1 Sep 2023.
  • 17 Mar 2023 New trial record

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