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A Phase 2, Randomized, Open-Label, Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer

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Trial Profile

A Phase 2, Randomized, Open-Label, Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 07 Oct 2025

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At a glance

  • Drugs Docetaxel (Primary) ; Lorigerlimab (Primary) ; Dexamethasone; Prednisone
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Therapeutic Use
  • Acronyms LORIKEET
  • Sponsors MacroGenics

Most Recent Events

  • 20 Mar 2025 According to a MacroGenics media release, the Company expects to provide a clinical update in the second half of 2025.
  • 13 Jan 2025 Status changed from recruiting to active, no longer recruiting.
  • 05 Nov 2024 According to a MacroGenics media release, company anticipates that its cash, cash equivalents and marketable securities balance of $200.4 million as of Sep 30, 2024, plus the $40.0 million upfront payment anticipated from TerSera related to the MARGENZA transaction, less an $8.0 million amendment fee to be paid to current commercialization partner, in addition to projected and anticipated future payments from partners should support its cash runway into 2026.

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