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A multicenter, randomized, placebo-controlled, double-blind, parallel-group study, to assess efficacy, safety and immunogenicity of JNJ-64042056, a phosphorylated tau targeted active immunotherapy, in participants with preclinical Alzheimer's disease

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Trial Profile

A multicenter, randomized, placebo-controlled, double-blind, parallel-group study, to assess efficacy, safety and immunogenicity of JNJ-64042056, a phosphorylated tau targeted active immunotherapy, in participants with preclinical Alzheimer's disease

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 04 Sep 2026

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At a glance

  • Drugs ACI 35.030 (Primary)
  • Indications Alzheimer's disease
  • Focus Registrational; Therapeutic Use
  • Acronyms ReTain
  • Sponsors AC Immune; Janssen-Cilag

Most Recent Events

  • 07 Jul 2026 This trial has been suspended in Spain and France.
  • 05 Jun 2026 Planned End Date changed from 22 Dec 2026 to 5 Jan 2027.
  • 13 May 2026 Planned End Date changed from 7 Jul 2034 to 22 Dec 2026.

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