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A Phase II, Open-Label, Multi-Drug, Multi-Center, Master Protocol to Evaluate the Efficacy and Safety of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer (GEMINI-Hepatobiliary)

Trial Profile

A Phase II, Open-Label, Multi-Drug, Multi-Center, Master Protocol to Evaluate the Efficacy and Safety of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer (GEMINI-Hepatobiliary)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 22 May 2025

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At a glance

  • Drugs Bevacizumab (Primary) ; Lenvatinib (Primary) ; Rilvegostomig (Primary) ; Volrustomig (Primary) ; Cisplatin; Gemcitabine
  • Indications Biliary cancer; Liver cancer; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms GEMINI-Hepatobiliary
  • Sponsors AstraZeneca

Most Recent Events

  • 19 May 2025 According to the Compugen media release, company partner, AstraZeneca, plans to present early primary analysis of sub-study 2 (cohort A) from this study as poster presentations.
  • 19 Feb 2025 Planned End Date changed from 26 Jan 2027 to 14 Dec 2026.
  • 21 Nov 2024 Planned End Date changed from 14 Dec 2026 to 26 Jan 2027.

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