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A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD

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Trial Profile

A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Jun 2025

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At a glance

  • Drugs Vorolanib (Primary) ; Aflibercept
  • Indications Wet age-related macular degeneration
  • Focus Registrational; Therapeutic Use
  • Acronyms LUGANO
  • Sponsors EyePoint Pharmaceuticals

Most Recent Events

  • 27 May 2025 Status changed from recruiting to active, no longer recruiting, according to an EyePoint Pharmaceuticals media release.
  • 27 May 2025 According to an EyePoint Pharmaceuticals media release, Brittney Statler is the Principal Investigator of this trial.
  • 27 May 2025 According to an EyePoint Pharmaceuticals media release, company announced it has enrolled and randomized over 400 patients in the Phase 3 LUGANO pivotal trial. Company expects to report topline data for the LUGANO trial in mid-2026.

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