Trial Profile

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations. Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations.

Status: Recruiting

Phase of Trial: Phase II/III

Latest Information Update: 28 May 2025

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At a glance

Drugs Pertuzumab (Primary) ; Trastuzumab (Primary)
Indications Bladder cancer; Colorectal cancer; Gallbladder cancer; Haematological malignancies; Lung cancer; Ovarian cancer; Pancreatic cancer; Prostate cancer; Salivary gland cancer; Skin cancer; Solid tumours
Focus Therapeutic Use
Acronyms DETERMINE

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