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A Phase II, Open-label, Single-arm, Multi-centre Study to Evaluate the Safety and Efficacy of Osimertinib With Amivantamab as First-line Treatment in Participants With Epidermal Growth Factor Receptor Mutation-Positive, Locally Advanced or Metastatic Non-small Cell Lung Cancer (OSTARA)

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Trial Profile

A Phase II, Open-label, Single-arm, Multi-centre Study to Evaluate the Safety and Efficacy of Osimertinib With Amivantamab as First-line Treatment in Participants With Epidermal Growth Factor Receptor Mutation-Positive, Locally Advanced or Metastatic Non-small Cell Lung Cancer (OSTARA)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 31 Mar 2025

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At a glance

  • Drugs Amivantamab (Primary) ; Osimertinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms OSTARA
  • Sponsors AstraZeneca

Most Recent Events

  • 27 Mar 2025 Planned End Date changed from 30 Apr 2028 to 1 Oct 2027.
  • 27 Mar 2025 Planned primary completion date changed from 30 Apr 2028 to 1 Oct 2027.
  • 27 Dec 2024 Status changed from recruiting to active, no longer recruiting.

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