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Phase 1a/1b Study of Itacitinib (INCB039110) for Cytokine Release Syndrome Prevention and Minimization of Immunosuppression Following Nonmyeloablative Related Partially HLA-mismatched Peripheral Blood Stem Cell Transplant (PBSCT) With High-dose Posttransplantation Cyclophosphamide in Older Patients (Age 60 Years)

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Trial Profile

Phase 1a/1b Study of Itacitinib (INCB039110) for Cytokine Release Syndrome Prevention and Minimization of Immunosuppression Following Nonmyeloablative Related Partially HLA-mismatched Peripheral Blood Stem Cell Transplant (PBSCT) With High-dose Posttransplantation Cyclophosphamide in Older Patients (Age 60 Years)

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 09 Oct 2025

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At a glance

  • Drugs Itacitinib (Primary)
  • Indications Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Multiple myeloma; Myelodysplastic syndromes
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 18 Sep 2025 Status changed from recruiting to active, no longer recruiting.
  • 06 Jul 2023 Status changed from not yet recruiting to recruiting.
  • 17 May 2023 Planned initiation date changed from 1 Apr 2023 to 1 Jul 2023.

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