Trial Profile

A Phase 1/1b Open-Label Dose-Escalation and Dose-Optimization Study of Bcl-2 Inhibitor BGB-21447 in Patients With Mature B-Cell Malignancies

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 26 Jun 2025

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At a glance

Drugs BGB 21447 (Primary)
Indications Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
Focus Adverse reactions; Therapeutic Use
Sponsors BeOne Medicines

Most Recent Events

20 May 2025 Planned number of patients changed from 85 to 112.
20 May 2025 Planned End Date changed from 1 Oct 2026 to 1 Apr 2027.
20 May 2025 Planned primary completion date changed from 1 Mar 2026 to 1 Apr 2027.

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