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A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ENLIGHTEN-Cirrhosis)

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Trial Profile

A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ENLIGHTEN-Cirrhosis)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Jun 2025

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At a glance

  • Drugs Pegozafermin (Primary)
  • Indications Liver cirrhosis; Non-alcoholic steatohepatitis
  • Focus Registrational; Therapeutic Use
  • Acronyms ENLIGHTEN-Cirrhosis
  • Sponsors 89bio

Most Recent Events

  • 27 Feb 2025 According to a 89bio media release, the company expects topline data from the histology cohorts of ENLIGHTEN-Cirrhosis in the first half of 2028.
  • 24 May 2024 Planned primary completion date changed from 1 Apr 2030 to 1 Jun 2028.
  • 22 May 2024 New source identified and integrated Clinicaltrials.gov record (NCT06419374).

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