Trial Profile

Window-of-opportunity Umbrella Platform Trial of Short-course Pre-operative Targeted Treatments in Patients With Molecularly Selected and Resectable Primary Colorectal Cancer: the UNICORN Study

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 11 Sep 2025

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At a glance

Drugs Balstilimab (Primary) ; Botensilimab (Primary) ; Durvalumab (Primary) ; Nivolumab (Primary) ; Panitumumab (Primary) ; Sotorasib (Primary) ; Trastuzumab-deruxtecan (Primary) ; Vorbipiprant (Primary)
Indications Adenocarcinoma; Colorectal cancer
Focus Therapeutic Use
Acronyms UNICORN

Most Recent Events

17 Jun 2025 Trial protocol amended with addition of CR-6086, Nivolumab, and Sotorasib drug.
11 Jun 2025 Planned number of patients changed from 112 to 140.
26 Feb 2025 According to an Agenus media release, data from the study is presented at ASCO GI 2025

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