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An Open-label, Phase 1, First-in-human, Dose Escalation Study to Evaluate the Safety, Tolerability, Maximum Tolerated or Administered Dose, Pharmacokinetics, Pharmacodynamics, and Tumor Response Profile of the Diacylglycerol Kinase Alpha Inhibitor (DGKαi) BAY 2862789 in Participants With Advanced Solid Tumors

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Trial Profile

An Open-label, Phase 1, First-in-human, Dose Escalation Study to Evaluate the Safety, Tolerability, Maximum Tolerated or Administered Dose, Pharmacokinetics, Pharmacodynamics, and Tumor Response Profile of the Diacylglycerol Kinase Alpha Inhibitor (DGKαi) BAY 2862789 in Participants With Advanced Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 18 Aug 2026

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At a glance

  • Drugs Pasodacigib (Primary)
  • Indications Non-small cell lung cancer; Solid tumours
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors Bayer

Most Recent Events

  • 18 Aug 2026 Last checked against Clinical Trials Information System record.
  • 18 Jul 2025 Planned primary completion date changed from 30 Jul 2025 to 25 Sep 2025.
  • 11 Jul 2025 Planned End Date changed from 30 Jul 2025 to 25 Sep 2025.

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