Trial Profile

DAREON™-5: An Open-label, Multi-center Phase II Dose Selection Trial of Intravenous BI 764532, a DLL3-targeting T Cell Engager, in Patients With Relapsed/Refractory Extensive-stage Small Cell Lung Cancer and in Patients With Other Relapsed/Refractory Neuroendocrine Carcinomas

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 14 Nov 2025

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At a glance

Drugs Obrixtamig (Primary)
Indications Large cell carcinoma; Lung cancer; Neuroendocrine tumours; Small cell lung cancer
Focus Adverse reactions; Therapeutic Use
Acronyms DAREON-5; DareonTM-5
Sponsors Boehringer Ingelheim

22 May 2025 According to a Boehringer Ingelheim media release, company will present the latest data from this trial at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting.
28 Mar 2025 Status changed from active, no longer recruiting to recruiting.
28 Mar 2025 Planned number of patients changed from 120 to 174.

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