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A Phase IIIb Single Arm, Open-label, Multicentre Study of Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (SIERRA)

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Trial Profile

A Phase IIIb Single Arm, Open-label, Multicentre Study of Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (SIERRA)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 25 Apr 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary)
  • Indications Liver cancer
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms SIERRA
  • Sponsors AstraZeneca

Most Recent Events

  • 10 Dec 2024 Planned End Date changed from 30 Dec 2025 to 31 Mar 2026.
  • 10 Dec 2024 Planned primary completion date changed from 30 Jun 2025 to 30 Sep 2025.
  • 12 Jun 2024 Planned number of patients changed from 140 to 110.

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