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An Open-label, Randomized Phase 3 Study to Evaluate Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or MK-1308A in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, as First-Line Treatment in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

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An Open-label, Randomized Phase 3 Study to Evaluate Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or MK-1308A in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, as First-Line Treatment in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 13 Oct 2024

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At a glance

  • Drugs Belzutifan (Primary) ; Lenvatinib (Primary) ; Pembrolizumab (Primary) ; Pembrolizumab/Quavonlimab (Primary)
  • Indications Renal cell carcinoma
  • Focus Registrational; Therapeutic Use
  • Sponsors Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 20 Jun 2024 Planned End Date changed from 11 Jun 2027 to 1 Dec 2026.
    • 20 Jun 2024 Planned primary completion date changed from 11 Jun 2027 to 1 Dec 2026.
    • 11 Mar 2024 Status changed from recruiting to active, no longer recruiting.

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