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Venetoclax plus Azacitidine versus Standard intensive Chemotherapy for Patients with newly diagnosed Acute Myeloid Leukemia (AML) and NPM1 Mutations eligible for intensive Treatment (VINCENT)

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Trial Profile

Venetoclax plus Azacitidine versus Standard intensive Chemotherapy for Patients with newly diagnosed Acute Myeloid Leukemia (AML) and NPM1 Mutations eligible for intensive Treatment (VINCENT)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 03 Sep 2026

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At a glance

  • Drugs Mitoxantrone (Primary) ; Venetoclax (Primary) ; Azacitidine; Cytarabine; Daunorubicin; Gemtuzumab ozogamicin
  • Indications Acute myeloid leukaemia
  • Focus Therapeutic Use
  • Acronyms VINCENT

Most Recent Events

  • 27 Aug 2026 Planned End Date changed from 1 Jun 2028 to 1 Sep 2030.
  • 27 Aug 2026 Planned primary completion date changed from 1 Sep 2028 to 1 Sep 2030.
  • 10 Feb 2025 According to Trial design presented at the 66th American Society of Hematology Annual Meeting and Exposition, Currently 18 centers are active.

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