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A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis With Randomized Withdrawal and Retreatment

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Trial Profile

A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis With Randomized Withdrawal and Retreatment

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 25 Jun 2025

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At a glance

  • Drugs Icotrokinra (Primary)
  • Indications Plaque psoriasis
  • Focus Registrational; Therapeutic Use
  • Acronyms ICONIC-LEAD
  • Sponsors Janssen Research & Development

Most Recent Events

  • 10 Apr 2025 According to Johnson & Johnson Media Release, company announced new icotrokinra (JNJ-2113) data from a subgroup analysis of ICONIC-LEADa, the first ever Phase 3 registrational study in moderate-to-severe plaque psoriasis (PsO) to assess efficacy and safety of a systemic therapy in adolescents and adults simultaneously.
  • 10 Apr 2025 Results published in the Johnson & Johnson Media Release
  • 08 Mar 2025 According to Johnson & Johnson Media Release, results from a subgroup analysis of the ICONIC-LEAD study evaluating icotrokinra in the adolescent population will be presented at a forthcoming medical meeting.

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