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A Phase 1b/2a, 2-Part Study; Part 1: Randomized, Double-Blind, Crossover, Dose-Escalation, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SGK-1 Kinase Inhibition by LQT-1213 on Dofetilide-Induced QTc Prolongation in Healthy Adult Subjects. Part 2: Single-Blind, Multiple-Dose, Safety Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LQT-1213 in Patients Diagnosed With Type 2 or 3 Long QT Syndrome

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Trial Profile

A Phase 1b/2a, 2-Part Study; Part 1: Randomized, Double-Blind, Crossover, Dose-Escalation, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SGK-1 Kinase Inhibition by LQT-1213 on Dofetilide-Induced QTc Prolongation in Healthy Adult Subjects. Part 2: Single-Blind, Multiple-Dose, Safety Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LQT-1213 in Patients Diagnosed With Type 2 or 3 Long QT Syndrome

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 May 2025

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At a glance

  • Drugs LQT-1213 (Primary)
  • Indications Long QT syndrome
  • Focus Adverse reactions; First in man; Pharmacodynamics
  • Acronyms WAVE-1
  • Sponsors Thryv Therapeutics

Most Recent Events

  • 13 May 2025 According to a Thryv Therapeutics media release, clinical data from Part 2 of the Wave I study were presented at the t the Heart Rhythm Society (HRS) Annual Meeting.
  • 26 Feb 2025 Status changed from recruiting to active, no longer recruiting.
  • 15 Oct 2024 According to a Thryv Therapeutics media release, company announced that the Full data from the Wave I Part 2 study in congenital LQTS Types 2 and 3 will be presented at an upcoming scientific conference in 2025.

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