Trial Profile

A multicentre, randomized trial in adults with de novo Philadelphia-Chromosome positive acute lymphoblastic leukemia to assess the efficacy of ponatinib versus imatinib in combination with low-intensity chemotherapy, to compare end of therapy with indication for SCT versus TKI, blinatumomab and chemotherapy in optimal responders and to evaluate blinatumomab in suboptimal responders (GMALL-EVOLVE)

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 01 May 2025

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At a glance

Drugs Blinatumomab (Primary) ; Ponatinib (Primary) ; Cyclophosphamide; Cytarabine; Cytarabine; Imatinib; Mercaptopurine; Methotrexate; Methotrexate; Pegaspargase; Prednisolone; Rituximab; Vindesine
Indications Precursor cell lymphoblastic leukaemia-lymphoma
Focus Therapeutic Use
Acronyms GMALL-EVOLVE

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