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A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

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Trial Profile

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Jun 2025

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At a glance

  • Drugs Navacaprant (Primary)
  • Indications Major depressive disorder
  • Focus Registrational; Therapeutic Use
  • Acronyms KOASTAL-3
  • Sponsors Neumora Therapeutics

Most Recent Events

  • 12 May 2025 According to Neumora Therapeutics media release, company anticipates reporting topline major depressive disorder data from KOASTAL-3 in the first quarter of 2026.
  • 27 Mar 2025 Planned End Date changed from 1 Jun 2025 to 1 Mar 2026.
  • 27 Mar 2025 Planned primary completion date changed from 1 Mar 2025 to 1 Feb 2026.

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