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A Prospective, Open-Label, Single-Arm, Phase II Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With Diffuse Large B-Cell Lymphoma (ACRUE)

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Trial Profile

A Prospective, Open-Label, Single-Arm, Phase II Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With Diffuse Large B-Cell Lymphoma (ACRUE)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 08 Aug 2026

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At a glance

  • Drugs Acalabrutinib (Primary) ; Rituximab (Primary) ; Rituximab (Primary)
  • Indications Diffuse large B cell lymphoma
  • Focus Adverse reactions
  • Acronyms ACRUE
  • Sponsors AstraZeneca

Most Recent Events

  • 02 Jun 2026 Planned End Date changed from 25 Mar 2029 to 22 Apr 2029.
  • 02 Jun 2026 Planned primary completion date changed from 25 Mar 2029 to 22 Apr 2029.
  • 05 May 2026 Planned End Date changed from 24 Aug 2027 to 25 Mar 2029.

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