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A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients with Sickle Cell Disease Who Are At Increased Risk for Primary Stroke

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Trial Profile

A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients with Sickle Cell Disease Who Are At Increased Risk for Primary Stroke

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 20 Sep 2025

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At a glance

  • Drugs Etavopivat (Primary) ; Hydroxycarbamide
  • Indications Sickle cell anaemia
  • Focus Pharmacodynamics
  • Acronyms HIBISCUS 3
  • Sponsors FORMA Therapeutics

Most Recent Events

  • 16 Jul 2025 Planned number of patients changed from 46 to 27.
  • 16 Jul 2025 Planned End Date changed from 18 May 2026 to 20 Sep 2027.
  • 16 Jul 2025 Planned primary completion date changed from 14 Jul 2025 to 20 Sep 2027.

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