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A Phase 3, Open Label, Randomized Study to Compare the Efficacy and Safety of Odronextamab (REGN1979), an Anti-CD20 x Anti-CD3 Bispecific Antibody, in Combination With Lenalidomide Versus Rituximab in Combination With Lenalidomide Therapy in Relapsed/Refractory Participants With Follicular Lymphoma and Marginal Zone Lymphoma (OLYMPIA-5)

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Trial Profile

A Phase 3, Open Label, Randomized Study to Compare the Efficacy and Safety of Odronextamab (REGN1979), an Anti-CD20 x Anti-CD3 Bispecific Antibody, in Combination With Lenalidomide Versus Rituximab in Combination With Lenalidomide Therapy in Relapsed/Refractory Participants With Follicular Lymphoma and Marginal Zone Lymphoma (OLYMPIA-5)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 14 Mar 2025

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At a glance

  • Drugs Odronextamab (Primary) ; Lenalidomide; Rituximab
  • Indications Follicular lymphoma; Marginal zone B-cell lymphoma
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms Olympia-5
  • Sponsors Regeneron Pharmaceuticals

    • Most Recent Events

    • 29 Aug 2024 Planned End Date changed from 4 Oct 2029 to 23 Jan 2029.
    • 29 Aug 2024 Planned primary completion date changed from 4 Oct 2029 to 23 Jan 2029.
    • 04 Jun 2024 Trial design presented at the 60th Annual Meeting of the American Society of Clinical Oncology.

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