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Phase 1, Open-Label Study of Autologous SIRPα-low Macrophages (SIRPant-M) Administered by Intratumoral Injection Alone or in Combination With Focal External-Beam Radiotherapy in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma

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Trial Profile

Phase 1, Open-Label Study of Autologous SIRPα-low Macrophages (SIRPant-M) Administered by Intratumoral Injection Alone or in Combination With Focal External-Beam Radiotherapy in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 26 Dec 2024

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At a glance

  • Drugs SI 101 (Primary)
  • Indications Adult T-cell leukaemia-lymphoma; Anaplastic large cell lymphoma; Chronic lymphocytic leukaemia; Cutaneous B-cell lymphoma; Cutaneous T-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Mycosis fungoides; Non-Hodgkin's lymphoma; Peripheral T-cell lymphoma; Sezary syndrome
  • Focus Adverse reactions
  • Sponsors SIRPant Immunotherapeutics

    • Most Recent Events

    • 20 Dec 2024 Planned End Date changed from 1 Mar 2025 to 1 Dec 2025.
    • 20 Dec 2024 Planned primary completion date changed from 1 Mar 2025 to 1 Jun 2025.
    • 12 Mar 2024 According to a SIRPant Immunotherapeutics media release, the first patient with advanced and refractory cutaneous T cell lymphoma has been dosed in this trial.

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