Trial Profile

A Phase 3b, Multi-center, Randomized, Parallel-group, Open-label, Non-inferiority Study Evaluating the Efficacy, Safety, and Tolerability of Oral Dolutegravir/Lamivudine Once-daily as a First-line Regimen Compared to Oral Bictegravir/Emtricitabine/Tenofovir Alafenamide Once Daily for Virologic Suppression and Maintenance in Antiretroviral Therapy Naive Adults Living With HIV

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 30 Sep 2025

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At a glance

Drugs Dolutegravir/lamivudine (Primary) ; Bictegravir/emtricitabine/tenofovir alafenamide
Indications HIV-1 infections
Focus Registrational; Therapeutic Use
Acronyms VOGUE
Sponsors ViiV Healthcare

28 May 2025 Planned End Date changed from 5 Oct 2026 to 23 Feb 2027.
28 May 2025 Planned primary completion date changed from 3 Nov 2025 to 24 Mar 2026.
28 May 2025 Status changed from recruiting to active, no longer recruiting.

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