Trial Profile

A Phase 3, Open Label, Multicenter, Randomized Study of First Line Tarlatamab in Combination With Durvalumab, Carboplatin and Etoposide Versus Durvalumab, Carboplatin and Etoposide in Untreated Extensive Stage Small-Cell Lung Cancer (DeLLphi-312)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 10 Dec 2025

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At a glance

26 Nov 2025 The protocol has been amended to addition in efficacy endpoint.
06 Nov 2025 According to BeOne Medicines media release, first subject is enrolled in this global Phase 3 trial for the treatment of first-line extensive-stage small cell lung cancer.
11 Aug 2025 Planned primary completion date changed from 20 Dec 2028 to 4 Jan 2029.

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