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A Phase 3, Open Label, Multicenter, Randomized Study of First Line Tarlatamab in Combination With Durvalumab, Carboplatin and Etoposide Versus Durvalumab, Carboplatin and Etoposide in Untreated Extensive Stage Small-Cell Lung Cancer (DeLLphi-312)

Trial Profile

A Phase 3, Open Label, Multicenter, Randomized Study of First Line Tarlatamab in Combination With Durvalumab, Carboplatin and Etoposide Versus Durvalumab, Carboplatin and Etoposide in Untreated Extensive Stage Small-Cell Lung Cancer (DeLLphi-312)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 28 Aug 2025

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At a glance

  • Drugs Tarlatamab (Primary) ; Carboplatin; Durvalumab; Etoposide
  • Indications Small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms DeLLphi-312
  • Sponsors Amgen

Most Recent Events

  • 11 Aug 2025 Planned primary completion date changed from 20 Dec 2028 to 4 Jan 2029.
  • 11 Aug 2025 Planned initiation date changed from 31 Jul 2025 to 29 Aug 2025.
  • 11 Aug 2025 Status changed from not yet recruiting to recruiting.

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