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A Phase 3 Open-label, Randomized Controlled Study to Evaluate the Efficacy and Safety of Petosemtamab Compared With Investigator's Choice Monotherapy Treatment in Previously Treated Patients With Incurable, Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma

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Trial Profile

A Phase 3 Open-label, Randomized Controlled Study to Evaluate the Efficacy and Safety of Petosemtamab Compared With Investigator's Choice Monotherapy Treatment in Previously Treated Patients With Incurable, Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 22 Nov 2025

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At a glance

  • Drugs Petosemtamab (Primary) ; Cetuximab; Docetaxel; Methotrexate
  • Indications Head and neck cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms LiGeR-HN2
  • Sponsors Merus

Most Recent Events

  • 22 May 2025 According to a Merus media release, company is looking forward to potentially sharing top line interim readout of one or both of our phase 3 trials in 2026.
  • 27 Feb 2025 According to a Merus media release, the company expects this trial to be substantially enrolled by YE25.
  • 17 Sep 2024 Trial design were presented at the 49th European Society for Medical Oncology Congress.

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