A Randomized, Double-Blind, Phase 3 Trial of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 19 Apr 2025

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At a glance

Drugs Adagrasib (Primary) ; Pembrolizumab (Primary)
Indications Non-small cell lung cancer
Focus Registrational; Therapeutic Use
Acronyms KRYSTAL-4
Sponsors Mirati Therapeutics

Most Recent Events

08 Apr 2025 Status changed from not yet recruiting to recruiting.
15 Mar 2025 Status changed from planning to not yet recruiting.
11 Aug 2023 New trial record

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