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A Prospective Non-interventional Study (NIS) of Trastuzumab DeRuxtecan (T-DXd) for Adult Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction (GEJ) AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen, Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies in a Real-world Setting in Europe (PROSPERITY)

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Trial Profile

A Prospective Non-interventional Study (NIS) of Trastuzumab DeRuxtecan (T-DXd) for Adult Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction (GEJ) AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen, Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies in a Real-world Setting in Europe (PROSPERITY)

Status: Active, no longer recruiting
Phase of Trial: Phase IV

Latest Information Update: 24 Aug 2026

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At a glance

  • Drugs Trastuzumab-deruxtecan (Primary) ; Irinotecan; Nivolumab; Paclitaxel; Pembrolizumab; Ramucirumab; Taxanes
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use
  • Acronyms PROSPERITY
  • Sponsors Daiichi Sankyo Company

Most Recent Events

  • 20 Aug 2026 Status changed from recruiting to active, no longer recruiting.
  • 08 Mar 2024 Planned number of patients changed from 368 to 257.
  • 06 Mar 2024 Status changed from not yet recruiting to recruiting.

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