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A Randomized, Partially Observer-blind, Dose-escalation, Phase I/II Trial Evaluating the Safety and Immunogenicity of Investigational RNA-based Mpox Vaccine Candidates

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Trial Profile

A Randomized, Partially Observer-blind, Dose-escalation, Phase I/II Trial Evaluating the Safety and Immunogenicity of Investigational RNA-based Mpox Vaccine Candidates

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 27 Oct 2025

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At a glance

  • Drugs BNT 166a (Primary) ; BNT 166c (Primary)
  • Indications Monkeypox
  • Focus Adverse reactions
  • Sponsors BioNTech

Most Recent Events

  • 22 Oct 2025 Actual primary completion date changed to 25 Aug 2025.
  • 13 Mar 2025 Status changed from recruiting to active, no longer recruiting.
  • 03 Dec 2024 Planned number of patients changed from 64 to 96.

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