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A Phase IIIb, Randomized, Multicenter, Open-label Study to Assess the Efficacy of Durvalumab Plus Tremelimumab Versus Pembrolizumab in Combination With Platinum-Based Chemotherapy for First-Line Treatment in Metastatic Non-Small Cell Lung Cancer Patients With Non-Squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS (TRITON)

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Trial Profile

A Phase IIIb, Randomized, Multicenter, Open-label Study to Assess the Efficacy of Durvalumab Plus Tremelimumab Versus Pembrolizumab in Combination With Platinum-Based Chemotherapy for First-Line Treatment in Metastatic Non-Small Cell Lung Cancer Patients With Non-Squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS (TRITON)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 24 Apr 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Tremelimumab (Primary) ; Carboplatin; Cisplatin; Pembrolizumab; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms TRITON
  • Sponsors AstraZeneca

Most Recent Events

  • 16 Oct 2024 Planned End Date changed from 14 Oct 2032 to 20 Mar 2031.
  • 14 Oct 2024 Planned End Date changed from 26 Aug 2033 to 14 Oct 2032.
  • 19 Sep 2024 Planned End Date changed from 20 Mar 2031 to 26 Aug 2033.

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