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A Phase I, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-Tumor Activity of RO7589831 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Harboring Microsatellite Instability (MSI) and/or Deficient Mismatch Repair (dMMR)

Trial Profile

A Phase I, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-Tumor Activity of RO7589831 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Harboring Microsatellite Instability (MSI) and/or Deficient Mismatch Repair (dMMR)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 11 Jun 2025

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At a glance

  • Drugs RG 6457 (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Roche

Most Recent Events

  • 04 Jun 2025 Preliminary results presented in the Vividion Therapeutics media release.
  • 04 Jun 2025 According to a Vividion Therapeutics media release, Preliminary data from a first-in-human study presented at the recent American Association for Cancer Research (AACR) Annual Meeting.
  • 30 Apr 2025 Results (n=44) presented at the 116th Annual Meeting of the American Association for Cancer Research

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