Trial Profile

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 26 Feb 2026

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At a glance

Drugs Capecitabine (Primary) ; Trastuzumab (Primary) ; Tucatinib (Primary)
Indications Advanced breast cancer; HER2 positive breast cancer; Male breast cancer
Focus Therapeutic Use
Acronyms CLIMB LMD

28 Jan 2026 Planned primary completion date changed from 5 Oct 2025 to 31 Dec 2026.
05 Jan 2024 Status changed from not yet recruiting to recruiting.
31 Aug 2023 New trial record

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