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A Multicenter, Open-label, Phase 1/1b Dose Finding, Safety, and Pharmacokinetic Study of MBRC-101, an Anti-EphA5 Monomethyl Auristatin E (MMAE) Antibody Drug Conjugate, in Advanced Refractory Solid Tumors

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A Multicenter, Open-label, Phase 1/1b Dose Finding, Safety, and Pharmacokinetic Study of MBRC-101, an Anti-EphA5 Monomethyl Auristatin E (MMAE) Antibody Drug Conjugate, in Advanced Refractory Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 22 Mar 2025

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At a glance

  • Drugs MBRC-101 (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Colorectal cancer; Gastric cancer; HER2 negative breast cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer
  • Focus Adverse reactions; First in man
  • Sponsors MBrace Therapeutics

    • Most Recent Events

    • 14 Feb 2025 Planned number of patients changed from 90 to 130.
    • 14 Feb 2025 Planned End Date changed from 1 Nov 2025 to 1 Nov 2026.
    • 14 Feb 2025 Planned primary completion date changed from 1 Jul 2025 to 1 Jul 2026.

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