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An Open-label, Multiple-cohort, Dose-finding, Investigator-initiated Trial to Evaluate the Safety, Tolerability, and Efficacy of HG205 RNA Base-Editing Therapy in Subjects with OTOF-p.Q829X Mutation-associated Hearing Loss

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An Open-label, Multiple-cohort, Dose-finding, Investigator-initiated Trial to Evaluate the Safety, Tolerability, and Efficacy of HG205 RNA Base-Editing Therapy in Subjects with OTOF-p.Q829X Mutation-associated Hearing Loss

Status: Withdrawn prior to enrolment
Phase of Trial: Phase 0

Latest Information Update: 16 Apr 2025

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At a glance

  • Drugs HG-205 (Primary)
  • Indications Hearing loss
  • Focus Adverse reactions
  • Acronyms SOUND
  • Sponsors HuidaGene Therapeutics

    • Most Recent Events

    • 10 Apr 2025 Status changed from not yet recruiting to withdrawn prior to enrolment.(Reason- Huidagene stopped this program as lack of patients in China )
    • 17 Mar 2025 Planned End Date changed from 28 Apr 2030 to 28 Apr 2031.
    • 17 Mar 2025 Planned primary completion date changed from 30 Jun 2025 to 30 Jun 2026.

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