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A Phase 1, Open-Label, Multicenter Study of INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

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Trial Profile

A Phase 1, Open-Label, Multicenter Study of INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 10 Jun 2025

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At a glance

  • Drugs INCA 033989 (Primary) ; Ruxolitinib (Primary)
  • Indications Essential thrombocythaemia; Myelofibrosis
  • Focus Adverse reactions
  • Acronyms LIMBER
  • Sponsors Incyte Corporation

Most Recent Events

  • 03 Jun 2025 According to an Incyte corporation media release, data from the study will be presented at the 2025 European Hematology Association (EHA) congress, held June 12 -15, 2025, in Milan.
  • 29 May 2025 Arms increased from 4 to 7. Protocol amended with the combination therapy of INCA033989 and ruxolitinib.
  • 29 May 2025 Planned number of patients changed from 140 to 230.

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