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A Window of Opportunity Trial Evaluating the Oral TGF-beta Receptor I Inhibitor Vactosertib in Patients Undergoing Standard of Care Chemoradiotherapy for Locally Advanced Esophageal Adenocarcinoma

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Trial Profile

A Window of Opportunity Trial Evaluating the Oral TGF-beta Receptor I Inhibitor Vactosertib in Patients Undergoing Standard of Care Chemoradiotherapy for Locally Advanced Esophageal Adenocarcinoma

Status: Suspended
Phase of Trial: Phase II

Latest Information Update: 28 May 2026

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At a glance

  • Drugs Vactosertib (Primary) ; Carboplatin; Docetaxel; Fluorouracil; Folinic acid; Oxaliplatin; Paclitaxel
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use

Most Recent Events

  • 08 May 2026 Planned number of patients changed from 25 to 30.
  • 08 May 2026 Status changed from recruiting to suspended because major revision are due.
  • 28 Nov 2024 Planned initiation date (estimated date of first participant enrollment) changed from 1 Oct 2024 to 1 Jan 2025.

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