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A Phase 1 Study to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of GEN1042 Monotherapy and in Combination With Pembrolizumab ± Chemotherapy in Japanese Subjects With Malignant Solid Tumors

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Trial Profile

A Phase 1 Study to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of GEN1042 Monotherapy and in Combination With Pembrolizumab ± Chemotherapy in Japanese Subjects With Malignant Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Feb 2025

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At a glance

  • Drugs GEN 1042 (Primary) ; Pembrolizumab (Primary) ; Carboplatin; Cisplatin; Fluorouracil
  • Indications Head and neck cancer; Non-small cell lung cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions
  • Sponsors Genmab

    • Most Recent Events

    • 20 Dec 2024 Planned number of patients changed from 30 to 42.
    • 20 Dec 2024 Planned End Date changed from 28 Feb 2027 to 26 Dec 2026.
    • 20 Dec 2024 Planned primary completion date changed from 23 Jul 2026 to 26 Mar 2026.

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