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Individual and Combined Endothelin Receptor and SGLT1/2 Antagonism in Adults With Type 1 Diabetes Mellitus and Chronic Kidney Disease: a Phase 2, Multicenter, Open-label Randomized Cross-over Trial

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Trial Profile

Individual and Combined Endothelin Receptor and SGLT1/2 Antagonism in Adults With Type 1 Diabetes Mellitus and Chronic Kidney Disease: a Phase 2, Multicenter, Open-label Randomized Cross-over Trial

Status: Not yet recruiting
Phase of Trial: Phase II

Latest Information Update: 25 Apr 2025

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At a glance

  • Drugs Ambrisentan (Primary) ; Sotagliflozin (Primary)
  • Indications Renal failure; Type 1 diabetes mellitus
  • Focus Therapeutic Use
  • Acronyms ASPIRE

Most Recent Events

  • 22 Apr 2025 Planned End Date changed from 1 Mar 2025 to 1 Dec 2027.
  • 22 Apr 2025 Planned primary completion date changed from 1 Mar 2025 to 1 Sep 2027.
  • 22 Apr 2025 Planned initiation date changed from 1 Mar 2024 to 1 Sep 2025.

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